|Other Accession||P25440, NP_005095, NM_005104|
|Reactivity||Human, Mouse, Rat, Dog, Guinea Pig, Horse, Bovine|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Dog, Guinea Pig, Bovine|
|Calculated MW||88 kDa|
|Alias Symbol||FSH, NAT, RNF3, FSRG1, RING3, D6S113E|
|Other Names||Bromodomain-containing protein 2, O2711, Really interesting new gene 3 protein, BRD2, KIAA9001, RING3|
|Target/Specificity||BRD2 is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-BRD2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||BRD2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.|
|Cellular Location||Nucleus. Note=Detected on chromatin and nucleosomes|
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