|Other Accession||P51816, NP_002016, NM_002025|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Guinea Pig, Horse, Bovine|
|Calculated MW||145 kDa|
|Alias Symbol||FMR2, FRAXE, MRX2, OX19, FMR2P|
|Other Names||AF4/FMR2 family member 2, Fragile X E mental retardation syndrome protein, Fragile X mental retardation 2 protein, FMR2P, Protein FMR-2, Protein Ox19, AFF2, FMR2, OX19|
|Target/Specificity||AFF2 belongs to the AF4 family. Defects in AFF2 are the cause of FRAXE. The exact function of AFF2 remains unknown.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-AFF2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||AFF2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.|
|Cellular Location||Nucleus speckle. Note=When splicing is inhibited, accumulates in enlarged speckles|
|Tissue Location||Brain (most abundant in hippocampus and amygdala), placenta and lung|
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