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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > TSC22D1 antibody - middle region
TSC22D1 antibody - middle region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q15714 |
| Other Accession | Q15714, NP_904358, NM_183422 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 110 kDa |
| Gene ID | 8848 |
|---|---|
| Alias Symbol | DKFZp686O19206, MGC17597, RP11-269C23.2, TGFB1I4, TSC22, Ptg-2 |
| Other Names | TSC22 domain family protein 1, Cerebral protein 2, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein, TSC22D1, KIAA1994, TGFB1I4, TSC22 |
| Target/Specificity | TSC22D1 belongs to the TSC-22/Dip/Bun family. It is a transcriptional repressor. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter.TSC22D1 encodes a transcription factor and belongs to the large family of early response genes.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1486 AB082525.1 1-1486 1487-2154 AK091854.1 1178-1845 2155-3858 AB082525.1 2155-3858 3859-4814 AB082525.1 3860-4815 4815-4837 CB138090.1 176-198 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TSC22D1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TSC22D1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSC22D1 (HGNC:16826) |
|---|---|
| Function | Transcriptional repressor (PubMed:10488076). Acts on the C- type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta- induced transcription of COL1A2; via its interaction with TFE3 at E- boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane; Peripheral membrane protein [Isoform 2]: Cytoplasm. Nucleus Mitochondrion |
| Tissue Location | Ubiquitously expressed in adult tissues (PubMed:8651929, PubMed:26752201). Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi (PubMed:12468551). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This is a rabbit polyclonal antibody against TSC22D1. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
$ 389.00
Cat# AI10142
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