|Other Accession||NM_024360, NP_077336|
|Reactivity||Human, Mouse, Rat, Pig, Bovine|
|Predicted||Human, Mouse, Rat, Pig, Bovine, Guinea Pig|
|Other Names||Transcription factor HES-1, Hairy and enhancer of split 1, Hairy-like protein, RHL, Hes1, Hes-1, Hl|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Hes1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Hes1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).|
|Tissue Location||Present in all tissues examined but highest in epithelial cells and in mesoderm-derived tissues such as embryonal muscle cells|
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