|Application ||WB, IHC|
|Other Accession||NM_001352, NP_001343|
|Reactivity||Human, Mouse, Rat, Pig, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog|
|Other Names||D site-binding protein, Albumin D box-binding protein, Albumin D-element-binding protein, Tax-responsive enhancer element-binding protein 302, TaxREB302, DBP|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-DBP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||DBP antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.|
|Tissue Location||Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity|
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Provided below are standard protocols that you may find useful for product applications.
Smith,J.S.,et al.,(2000) Genomics 64(1),44-50Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Okazaki, H. et al. Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma. Cancer Res. 74, 543-51 (2014). WB, Human, Pig, Horse, Guinea pig, Sheep, Dog, Bovine, Mouse, Rat24253377Nakabayashi, H. et al. Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cells. Biochem. Biophys. Res. Commun. 434, 370-5 (2013). WB, Human, Pig, Horse, Guinea pig, Sheep, Dog, Bovine, Mouse, Rat23567972
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