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Eya1 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Eya1 antibody - middle region AI10361
    WB Suggested Anti-Eya1 Antibody
    Titration: 1. μg/ml
    Positive Control: Mouse Heart
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P97767
Other Accession NM_010164, NP_034294
Reactivity Human, Mouse, Rat, Zebrafish, Pig, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Zebrafish, Pig, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 64kDa
Additional Information
Alias Symbol bor
Other Names Eyes absent homolog 1,,, Eya1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Eya1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsEya1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Eya1
Function Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
Cellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Location Extensively expressed in cranial placodes, branchial arches, CNS and developing eye and nose
Research Areas
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$ 293.00
Cat# AI10361
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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