|Other Accession||NM_001007804, NP_001007805|
|Reactivity||Human, Mouse, Rat, Zebrafish, Goat, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Zebrafish, Chicken, Bovine, Guinea Pig, Dog|
|Alias Symbol||D11moh34, MGC105799, RGD1310144|
|Other Names||Vacuolar-sorting protein SNF8, ELL-associated protein of 30 kDa, ESCRT-II complex subunit VPS22, Snf8, Eap30|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Snf8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Snf8 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL.Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).|
|Cellular Location||Cytoplasm. Endosome membrane. Nucleus. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.|
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