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PIR antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | O00625 |
| Other Accession | NM_003662, NP_003653 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32kDa |
| Gene ID | 8544 |
|---|---|
| Other Names | Pirin, 1.13.11.24, Probable quercetin 2, 3-dioxygenase PIR, Probable quercetinase, PIR |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-PIR antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PIR antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PIR |
|---|---|
| Function | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). |
| Cellular Location | Nucleus. Cytoplasm Note=Predominantly localized in dot-like subnuclear structures Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. |
| Tissue Location | Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Adams,M. (2005) J. Biol. Chem. 280 (31), 28675-28682 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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