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>   home   >   Products   >   Primary Antibodies   >   PIR antibody - C-terminal region   

PIR antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - PIR antibody - C-terminal region AI10545
    WB Suggested Anti-PIR Antibody Titration: 1.25μg/ml
    Positive Control: HepG2 cell lysate
  • IHC - PIR antibody - C-terminal region AI10545
    Human Lung
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00625
Other Accession NM_003662, NP_003653
Reactivity Human, Mouse, Rat, Pig, Bovine, Dog
Predicted Human, Mouse, Rat, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 32kDa
Additional Information
Gene ID 8544
Other Names Pirin,, Probable quercetin 2, 3-dioxygenase PIR, Probable quercetinase, PIR
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-PIR antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPIR antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIR
Function Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
Cellular Location Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression
Tissue Location Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level) Expressed in all tissues, with highest level of expression in heart and liver.
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Adams,M. (2005) J. Biol. Chem. 280 (31), 28675-28682 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 232.00
Cat# AI10545
(40 western blots)
Availability: 2-3 days
Bulk Size
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