SMPDL3B antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | Q92485 |
Other Accession | NM_014474, NP_055289 |
Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Horse, Bovine, Dog |
Predicted | Human, Mouse, Rat, Pig, Chicken, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 52kDa |
Gene ID | 27293 |
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Alias Symbol | ASML3B |
Other Names | Acid sphingomyelinase-like phosphodiesterase 3b, ASM-like phosphodiesterase 3b, 3.1.4.-, SMPDL3B, ASML3B |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SMPDL3B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | SMPDL3B antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SMPDL3B |
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Synonyms | ASML3B, ASMLPD |
Function | Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). |
Cellular Location | Secreted. Cell membrane {ECO:0000250|UniProtKB:P58242}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P58242} |
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Provided below are standard protocols that you may find useful for product applications.
References
Strausberg,R.L., et al., (2002) Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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