|Application ||WB, IHC|
|Other Accession||NM_001449, NP_001440|
|Reactivity||Human, Mouse, Rat, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Sheep, Bovine, Guinea Pig, Dog|
|Alias Symbol||KYOT, SLIM, FHL-1, FHL1A, FHL1B, FLH1A, SLIM1, XMPMA, SLIM-1, SLIMMER|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-FHL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FHL1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
McGrath,M.J., et al., (2003) Am. J. Physiol., Cell Physiol. 285 (6), C1513-C1526Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Windpassinger, C. et al. An X-linked myopathy with postural muscle atrophy and generalized hypertrophy, termed XMPMA, is caused by mutations in FHL1. Am. J. Hum. Genet. 82, 88-99 (2008). WB, IHC, Mouse, Human, Sheep, Dog, Bovine, Horse, Guinea pig, Rat, Rabbit18179888Quinzii, C. M. et al. X-linked dominant scapuloperoneal myopathy is due to a mutation in the gene encoding four-and-a-half-LIM protein 1. Am. J. Hum. Genet. 82, 208-13 (2008). WB, Mouse, Human, Sheep, Dog, Bovine, Horse, Guinea pig, Rat, Rabbit18179901Schoser, B. et al. Consequences of mutations within the C terminus of the FHL1 gene. Neurology 73, 543-51 (2009). WB, Mouse, Human, Sheep, Dog, Bovine, Horse, Guinea pig, Rat, Rabbit19687455Gueneau, L. et al. Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy. Am. J. Hum. Genet. 85, 338-53 (2009). IHC, Mouse, Human, Sheep, Dog, Bovine, Horse, Guinea pig, Rat, Rabbit19716112Sharma, P., Shathasivam, T., Ignatchenko, V., Kislinger, T. & Gramolini, A. O. Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis. Mol. Biosyst. 7, 1185-96 (2011). WB, Mouse, Human, Sheep, Dog, Bovine, Horse, Guinea pig, Rat, Rabbit21246116Dong, R. et al. Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures. Cell. Immunol. 272, 1-10 (2011). WB, Mouse, Human, Sheep, Dog, Bovine, Horse, Guinea pig, Rat, Rabbit22053194Koike, K. et al. High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer. Int. J. Oncol. 42, 141-50 (2013). WB, IHC, Mouse, Human, Sheep, Dog, Bovine, Horse, Guinea pig, Rat, Rabbit23123766Fujii, T. et al. A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles. J. Neurol. Sci. 343, 206-10 (2014). WB, Mouse, Human, Sheep, Dog, Bovine, Horse, Guinea pig, Rat, Rabbit24928078
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