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PCGF3 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q3KNV8 |
| Other Accession | NM_006315, NP_006306 |
| Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Chicken, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28kDa |
| Gene ID | 10336 |
|---|---|
| Alias Symbol | RNF3, DONG1, RNF3A |
| Other Names | Polycomb group RING finger protein 3, RING finger protein 3A, PCGF3, RNF3, RNF3A |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PCGF3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PCGF3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PCGF3 |
|---|---|
| Synonyms | RNF3, RNF3A |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1- like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). |
| Cellular Location | Nucleus. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8BTQ0}. Note=Recruited by the non- coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. {ECO:0000250|UniProtKB:Q8BTQ0} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Ota,T., et al., (2004) Nat. Genet. 36 (1), 40-45Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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