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Uhrf2 antibody - N-terminal region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q7TMI3 |
| Other Accession | NM_144873, NP_659122 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rabbit, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 90kDa |
| Gene ID | 109113 |
|---|---|
| Alias Symbol | 2310065A22Rik, AI426270, AW214556, D130071B19Rik, Nirf |
| Other Names | E3 ubiquitin-protein ligase UHRF2, 6.3.2.-, NIRF, Np95-like ring finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, Ubiquitin-like PHD and RING finger domain-containing protein 2, Ubiquitin-like-containing PHD and RING finger domains protein 2, Uhrf2, Nirf |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Uhrf2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Uhrf2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Uhrf2 |
|---|---|
| Synonyms | Nirf |
| Function | E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair. Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:23434322, PubMed:28402695). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (PubMed:28115522). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thus inducing G1 arrest. Ubiquitinates also PCNP leading to its degradation by the proteasome. Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation. Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation. Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00358, ECO:0000269|PubMed:21598301}. Chromosome {ECO:0000250|UniProtKB:Q96PU4}. Note=Enriched at genomic loci that are enriched for 5-hydroxy-methylcytosine (5hmC) {ECO:0000250|UniProtKB:Q96PU4} |
| Tissue Location | Mostly detected in several tissues, including the thymus, spleen, lung, adrenal gland, and ovary. In addition, found in several tissues in the brain (cerebellum, hippocampus, and cerebral cortex). |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI10727
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