|Other Accession||NM_017288, NP_058984|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Bovine, Dog|
|Other Names||Sodium channel subunit beta-1, Scn1b|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Scn1b antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Scn1b Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in brain, heart, skeletal muscle and spinal cord|
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