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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   ZIC2 antibody - C-terminal region   

ZIC2 antibody - C-terminal region

Rabbit Polyclonal Antibody

  • IHC - ZIC2 antibody - C-terminal region AI10893
    Human Skin
  • WB - ZIC2 antibody - C-terminal region AI10893

    WB Suggested Anti-ZIC2 Antibody Titration: 0.2-1 μg/ml
    Positive Control: HepG2 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95409
Other Accession NM_007129, NP_009060
Reactivity Human, Mouse, Rat
Predicted Human, Pig
Host Rabbit
Clonality Polyclonal
Calculated MW 55kDa
Additional Information
Gene ID 7546
Alias Symbol HPE5
Other Names Zinc finger protein ZIC 2, Zinc finger protein of the cerebellum 2, ZIC2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ZIC2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsZIC2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZIC2
Function Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Cellular Location Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity).
Research Areas
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Brown,L., (2005) Hum. Mol. Genet. 14 (3), 411-420 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 293.00
Cat# AI10893
(40 western blots)
Availability: 2-3 days
Bulk Size
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