|Other Accession||NM_030776, NP_110403|
|Alias Symbol||DAI, DLM1, DLM-1, C20orf183|
|Other Names||Z-DNA-binding protein 1, Tumor stroma and activated macrophage protein DLM-1, ZBP1, C20orf183, DLM1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-ZBP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ZBP1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).|
|Tissue Location||Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen Expressed to a lesser extent in thymus, lung and liver|
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