|Other Accession||NM_001012638, NP_001012656|
|Reactivity||Human, Mouse, Rat, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Bovine|
|Calculated MW||45 KDa|
|Other Names||Adrenocortical dysplasia protein, Acd|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Acd antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Acd antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity (By similarity). Plays a role in shelterin complex assembly. May play an essential role in organogenesis of the developing embryo.|
|Cellular Location||Nucleus. Chromosome, telomere|
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