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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Acd antibody - C-terminal region   

Acd antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Acd antibody - C-terminal region AI11035

    WB Suggested Anti-Acd Antibody Titration: 0.2-1 μg/ml
    Positive Control: Mouse Muscle
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q5EE38
Other Accession NM_001012638, NP_001012656
Reactivity Human, Mouse, Rat, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 45 KDa
Additional Information
Gene ID 497652
Other Names Adrenocortical dysplasia protein, Acd
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Acd antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsAcd antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Acd
Function Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity (By similarity). May play a role in organogenesis (PubMed:15537664).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q96AP0}. Chromosome, telomere {ECO:0000250|UniProtKB:Q96AP0}
Tissue Location Ubiquitous..
Research Areas
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$ 293.00
Cat# AI11035
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