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Egr1 antibody - C-terminal region
Rabbit Polyclonal Antibody
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Application 
| WB, IHC |
|---|---|
| Primary Accession | P08046 |
| Other Accession | NM_007913, NP_031939 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Pig, Chicken, Sheep, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56kDa |
| Gene ID | 13653 |
|---|---|
| Alias Symbol | A530045N19Rik, ETR103, Egr-1, Krox-1, Krox-24, Krox24, NGF1-A, NGFI-A, NGFIA, TIS8, Zenk, Zfp-6, Zif268, egr |
| Other Names | Early growth response protein 1, EGR-1, Nerve growth factor-induced protein A, NGFI-A, Transcription factor Zif268, Zinc finger protein Krox-24, Egr1, Egr-1, Krox-24 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Egr1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Egr1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Egr1 |
|---|---|
| Synonyms | Egr-1, Krox-24 {ECO:0000303|PubMed:25110 |
| Function | Transcriptional regulator (PubMed:8336701, PubMed:8703054, PubMed:15958557). Recognizes and binds to the DNA sequence 5'- GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:8703054, PubMed:15958557, PubMed:2028256, PubMed:8939742). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557). Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557). Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation (PubMed:15958557). Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy (PubMed:15265859). Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia (PubMed:11100120). Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (PubMed:8703054). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription (PubMed:26471974). Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (PubMed:29138967). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:P18146} |
| Tissue Location | Detected in lung vasculature and in mononuclear phagocytes (PubMed:11100120). Detected in liver (at protein level) (PubMed:15265859). Expressed in the liver in a circadian manner (PubMed:26471974). |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI11043
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