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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   Egr1 antibody - C-terminal region   

Egr1 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - Egr1 antibody - C-terminal region AI11043
    Sample Type : Frog brain
    Primary Antibody Dilution : 1:500
    Secondary Antibody : Biotinylated goat anti-rabbit Secondary Antibody Dilution : 1:200 Color/Signal Descriptions : Black: EGR1
    Gene Name : Egr1 a Submitted by : Eva Fischer, Colorado State University
  • IHC - Egr1 antibody - C-terminal region AI11043
    Sample Type : Frog brain
    Primary Antibody Dilution : 1:500
    Secondary Antibody : Biotinylated goat anti-rabbit Secondary Antibody Dilution : 1:200 Color/Signal Descriptions : Black: EGR1
    Gene Name : Egr1 a Submitted by : Eva Fischer, Colorado State University
  • WB - Egr1 antibody - C-terminal region AI11043

    WB Suggested Anti-Egr1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: Mouse Heart
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P08046
Other Accession NM_007913, NP_031939
Reactivity Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Pig, Chicken, Sheep, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 56kDa
Additional Information
Gene ID 13653
Alias Symbol A530045N19Rik, ETR103, Egr-1, Krox-1, Krox-24, Krox24, NGF1-A, NGFI-A, NGFIA, TIS8, Zenk, Zfp-6, Zif268, egr
Other Names Early growth response protein 1, EGR-1, Nerve growth factor-induced protein A, NGFI-A, Transcription factor Zif268, Zinc finger protein Krox-24, Egr1, Egr-1, Krox-24
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Egr1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsEgr1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Egr1
Synonyms Egr-1, Krox-24 {ECO:0000303|PubMed:25110
Function Transcriptional regulator (PubMed:8336701, PubMed:8703054, PubMed:15958557). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:8703054, PubMed:15958557, PubMed:2028256, PubMed:8939742). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557). Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557). Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation (PubMed:15958557). Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy (PubMed:15265859). Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia (PubMed:11100120). Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (PubMed:8703054).
Cellular Location Nucleus Cytoplasm {ECO:0000250|UniProtKB:P18146}
Tissue Location Detected in lung vasculature and in mononuclear phagocytes (PubMed:11100120). Detected in liver (at protein level) (PubMed:15265859). Detected in lung vasculature and in mononuclear phagocytes (PubMed:11100120)
Research Areas
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$ 293.00
Cat# AI11043
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