|Other Accession||NM_008260, NP_032286|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Horse, Bovine, Dog|
|Alias Symbol||Hnf-3g, Hnf3g, Tcf-3g, Tcf3g|
|Other Names||Hepatocyte nuclear factor 3-gamma, HNF-3-gamma, HNF-3G, Forkhead box protein A3, Foxa3, Hnf3g, Tcf-3g, Tcf3g|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Foxa3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Foxa3 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Hnf3g, Tcf-3g, Tcf3g|
|Function||Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility.|
|Tissue Location||Restricted mainly to endoderm-derived tissues (lung, liver, stomach, and small intestine), also present additionally in ovary, testis, heart, and adipose tissue, but missing from lung.|
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