|Application ||WB, IHC|
|Other Accession||NM_010136, NP_034266|
|Reactivity||Mouse, Rat, Pig, Bovine, Dog|
|Alias Symbol||C77258, Tbr2, TBR-2|
|Other Names||Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2, Eomes, Tbr2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Eomes antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Eomes antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.|
|Tissue Location||Expressed in CD8+ T-cells.|
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