|Other Accession||NM_018809, NP_061279|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Alias Symbol||PTF1-p48, PTF1p48, bHLHa29|
|Other Names||Pancreas transcription factor 1 subunit alpha, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48, Ptf1a, Ptf1p48|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Ptf1a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Ptf1a Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.|
|Cellular Location||Nucleus. Cytoplasm. Note=In the cytoplasm loses its ability to form the PTF1 complex|
|Tissue Location||Expressed in precursors of pancreatic islets, acini and ducts.|
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