|Other Accession||NM_001037204, NP_001032281|
|Reactivity||Mouse, Rat, Rabbit, Horse|
|Predicted||Mouse, Rat, Rabbit, Pig, Horse|
|Other Names||TATA box-binding protein-associated factor RNA polymerase I subunit A, TATA box-binding protein-associated factor 1A, TBP-associated factor 1A, Transcription initiation factor SL1/TIF-IB subunit A, Taf1a|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Taf1a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Taf1a Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre- initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).|
|Cellular Location||Nucleus. EMBL; BC107466; AAI07467.1; -; mRNA RefSeq; NP_001032281.1; NM_001037204.1 RefSeq; XP_017454352.1; XM_017598863.1 UniGene; Rn.163238; - STRING; 10116.ENSRNOP00000062006; - PaxDb; Q3B7U2; - PRIDE; Q3B7U2; - GeneID; 360893; - KEGG; rno:360893; - UCSC; RGD:1305698; rat CTD; 9015; - RGD; 1305698; Taf1a eggNOG; ENOG410IEFS; Eukaryota eggNOG; ENOG410YWVA; LUCA HOVERGEN; HBG053462; - InParanoid; Q3B7U2; - KO; K15212; - PhylomeDB; Q3B7U2; - PRO; PR:Q3B7U2; - Proteomes; UP000002494; Unplaced GO; GO:0000120; C:RNA polymerase I transcription factor complex; IBA:GO_Central GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW GO; GO:0006360; P:transcription from RNA polymerase I promoter; IBA:GO_Central InterPro; IPR016629; RNA_pol_I_TAF1A/TAFI48 PIRSF; PIRSF015161; TAFI48; 1 1: Evidence at protein level; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 453 TATA box-binding protein-associated factor RNA polymerase I subunit A /FTId=PRO_0000227989 SEQUENCE 453 AA; 53021 MW; 3E36DF2E2D043B36 CRC64; MMSDFSEELT KLAGAEDNPE TSEFSKTRMH FPWLQKHIEA VVTGGKKRKD FAQTTSACLS FLQEALLKHQ WCRAAEYMHS YLQTLEDSDT YRKQAAPEII WKLGSEILFY HPKSNVETFS SFADRMKNIG VLNYLKISLQ HALYLLHHGM LEDANRNLSE AETWRYGEKS ASQEVLIKLV QAYKGLLQHY SWSKKKMELS ELDEDDYAYT AKSRNMLSQS SKTSTNICTL IKTPGVWDPF VKSYVEMLEF YGDQDGAREL LTNYAYDEKF PSNPNAHVYL YEFLKREKAP RAKLISVLKI LHEIVPSHSL MLEFHTLLRK SETEEHRKLG LAVLFEVLDF SGCTKNITAW KYLAKYLKQT LMESHREWVE EEWKSRRNWW PAFHFSFFWA KSDWKADAEL ACEKAFVAGI LLGKGCRYFR YILKQDHETL KKKIKRMKKS VKKYTIVNPG VHT|
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