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L3mbtl antibody - middle region

Rabbit Polyclonal Antibody

  • WB - L3mbtl antibody - middle region AI11293

    WB Suggested Anti-L3mbtl Antibody Titration: 0.2-1 μg/ml
    Positive Control: Mouse Kidney
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession A2A5N8
Other Accession XM_485097, XP_485097
Reactivity Human, Mouse, Rat, Rabbit, Horse, Dog
Predicted Rabbit, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 67kDa
Additional Information
Gene ID 241764
Alias Symbol C630004G01, KIAA0681, L3MBTL1, mKIAA0681, L3mbtl
Other Names Lethal(3)malignant brain tumor-like protein 1, H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog, L3mbtl1, Kiaa0681, L3mbt, L3mbtl
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-L3mbtl antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsL3mbtl antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name L3mbtl1
Synonyms Kiaa0681, L3mbt, L3mbtl
Function Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity).
Cellular Location Nucleus. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex (By similarity).
Tissue Location Highly expressed in brain, testis, eyes, and ES cells.
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$ 293.00
Cat# AI11293
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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