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SCN3B antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NY72 |
| Other Accession | NM_018400, NP_060870 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24kDa |
| Gene ID | 55800 |
|---|---|
| Alias Symbol | HSA243396, SCNB3 |
| Other Names | Sodium channel subunit beta-3, SCN3B, KIAA1158 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SCN3B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SCN3B antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCN3B (HGNC:20665) |
|---|---|
| Synonyms | KIAA1158 |
| Function | Voltage-gated sodium channels regulatory subunit that modulates channel gating kinetics (PubMed:20558140, PubMed:21051419). Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in the atrium. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Kimura,K., et al., (2006) Genome Res. 16 (1), 55-65Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Hu, D. et al. A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype. Circ. Cardiovasc. Genet. 2, 270-8 (2009). WB, Mouse, Human, H, Rabbit, Bovine, Rat, Dog, Guinea pig20031595Ho, C., Zhao, J., Malinowski, S., Chahine, M. & O’Leary, M. E. Differential expression of sodium channel β subunits in dorsal root ganglion sensory neurons. J. Biol. Chem. 287, 15044-53 (2012). WB, Mouse, Human, H, Rabbit, Bovine, Rat, Dog, Guinea pig22408255
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