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Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UNS1 |
| Other Accession | NM_003920, NP_003911 |
| Reactivity | Human, Mouse, Rat, Sheep, Horse, Yeast, Bovine, Dog |
| Predicted | Human, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 139kDa |
| Gene ID | 8914 |
|---|---|
| Alias Symbol | TIM, TIM1, hTIM |
| Other Names | Protein timeless homolog, hTIM, TIMELESS {ECO:0000312|EMBL:AAH50557.1} |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-TIMELESS antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TIMELESS antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TIMELESS {ECO:0000312|EMBL:AAH50557.1} |
|---|---|
| Function | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis |
Citations (0)
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info@abgent.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Sangoram,A.M., (2005) Mol. Cell. Biol. 25 (8), 3109-3116Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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$ 232.00
Cat# AI11410
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