|Other Accession||NM_007265, NP_009196|
|Reactivity||Human, Rat, Rabbit, Pig, Goat, Horse, Bovine|
|Predicted||Human, Rabbit, Pig, Goat, Horse, Bovine, Dog|
|Alias Symbol||GCR2, HSGT1|
|Other Names||Protein SGT1, hSGT1, Protein ecdysoneless homolog, Suppressor of GCR2, ECD, SGT1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ECD antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ECD antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly is located in the cytoplasm.|
|Tissue Location||Highly expressed in muscle and heart. Over- expressed in pancreatic and breast cancers|
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