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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ECD antibody - middle region   

ECD antibody - middle region

Rabbit Polyclonal Antibody

  • WB - ECD antibody - middle region AI11476

    WB Suggested Anti-ECD Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: ACHN cell lysate
    ECD is supported by BioGPS gene expression data to be expressed in ACHN
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95905
Other Accession NM_007265, NP_009196
Reactivity Human, Rat, Rabbit, Pig, Goat, Horse, Bovine
Predicted Human, Rabbit, Pig, Goat, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Additional Information
Gene ID 11319
Alias Symbol GCR2, HSGT1
Other Names Protein SGT1, hSGT1, Protein ecdysoneless homolog, Suppressor of GCR2, ECD, SGT1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ECD antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsECD antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ECD
Function Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Cellular Location Cytoplasm. Nucleus. Note=Predominantly is located in the cytoplasm.
Tissue Location Highly expressed in muscle and heart. Over- expressed in pancreatic and breast cancers
Research Areas
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$ 293.00
Cat# AI11476
Availability: 2-3 days
Bulk Size
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