SART3 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q15020 |
Other Accession | NM_014706, NP_055521 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 110kDa |
Gene ID | 9733 |
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Alias Symbol | KIAA0156, MGC138188, RP11-13G14, TIP110, p110(nrb), P100, p110, DSAP1 |
Other Names | Squamous cell carcinoma antigen recognized by T-cells 3, SART-3 {ECO:0000312|EMBL:BAA78384.1}, Tat-interacting protein of 110 kDa, Tip110, p110 nuclear RNA-binding protein, SART3 (HGNC:16860) |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SART3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | SART3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SART3 (HGNC:16860) |
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Function | U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non- canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). |
Cellular Location | Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus speckle. Cytoplasm |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
References
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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