|Other Accession||NM_022465, NP_071910|
|Reactivity||Human, Mouse, Pig|
|Alias Symbol||EOS, KIAA1782, ZNFN1A4|
|Other Names||Zinc finger protein Eos, Ikaros family zinc finger protein 4, IKZF4, KIAA1782, ZNFN1A4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-IKZF4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||IKZF4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).|
|Tissue Location||Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K- 562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.|
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Provided below are standard protocols that you may find useful for product applications.
Perdomo,J. (2002) Eur. J. Biochem. 269 (23), 5885-5892 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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