|Other Accession||NM_001033901, NP_001029073|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Mouse, Rat, Rabbit, Pig, Bovine, Dog|
|Other Names||Speckle targeted PIP5K1A-regulated poly(A) polymerase, Star-PAP, 188.8.131.52, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase, 184.108.40.206, Tut1, Rbm21|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Tut1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Tut1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication- dependent histone mRNA degradation (By similarity).|
|Cellular Location||Nucleus, nucleolus. Nucleus speckle|
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