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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Ccnd1 antibody - C-terminal region   

Ccnd1 antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - Ccnd1 antibody - C-terminal region AI11618

    WB Suggested Anti-Ccnd1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: Mouse Small Intestine
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P25322
Other Accession NM_007631, NP_031657
Reactivity Human, Mouse, Rat, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 33kDa
Additional Information
Gene ID 12443
Alias Symbol AI327039, Cyl-1, PRAD1, bcl-1, cD1
Other Names G1/S-specific cyclin-D1, Ccnd1, Cyl-1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Ccnd1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCcnd1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ccnd1
Synonyms Cyl-1
Function Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity).
Cellular Location Nucleus. Cytoplasm. Membrane. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members
Research Areas
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$ 293.00
Cat# AI11618
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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