Kbtbd5 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9D783 |
Other Accession | NM_028202, NP_082478 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
Predicted | Rabbit, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 69kDa |
Gene ID | 72330 |
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Alias Symbol | 2310024D23Rik, Kbtbd5 |
Other Names | Kelch-like protein 40, Kelch repeat and BTB domain-containing protein 5, Klhl40, Kbtbd5 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Kbtbd5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Kbtbd5 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Klhl40 {ECO:0000312|MGI:MGI:1919580} |
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Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:25940086). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (PubMed:25940086). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (PubMed:24960163). |
Cellular Location | Cytoplasm. Cytoplasm, myofibril, sarcomere, A band Cytoplasm, myofibril, sarcomere, I band |
Tissue Location | Specifically expressed in skeletal muscles in embryonic, neonatal and adults (PubMed:24960163, PubMed:25940086) Expressed in various types of muscles, including extensor digitorum longus, gastrocnemius, soleus, diaphragm, masseter and heart (at protein level). Not detected in brain, liver and lung (at protein level). |
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