|Other Accession||NM_052804, NP_434691|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Bovine, Dog|
|Predicted||Mouse, Rat, Rabbit, Pig, Chicken, Bovine|
|Alias Symbol||FMRP, Fmr1|
|Other Names||Fragile X mental retardation protein 1 homolog, FMRP, Protein FMR-1, Fmr1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Fmr1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Fmr1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression. RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. Involved in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C) (By similarity).|
|Cellular Location||Cytoplasm. Nucleus, nucleolus|
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