|Other Accession||NM_012469, NP_036601|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Bovine, Dog|
|Predicted||Rabbit, Chicken, Horse, Dog|
|Alias Symbol||ANT-1, TOM, ANT1, Prp6, hPrp6, U5-102K, C20orf14|
|Other Names||Pre-mRNA-processing factor 6, Androgen receptor N-terminal domain-transactivating protein 1, ANT-1, PRP6 homolog, U5 snRNP-associated 102 kDa protein, U5-102 kDa protein, PRPF6, C20orf14|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-PRPF6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PRPF6 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Fan,S., (2006) Biochem. Biophys. Res. Commun. 341 (1), 192-201Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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