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> home > Products > Primary Antibodies > Antibody Collections > Zebrafish > CRMP1 antibody - C-terminal region
CRMP1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q14194 |
| Other Accession | NM_001313, NP_001304 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Pig, Chicken, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 62kDa |
| Gene ID | 1400 |
|---|---|
| Alias Symbol | DPYSL1, DRP-1, DRP1, CRMP-1, ULIP-3 |
| Other Names | Dihydropyrimidinase-related protein 1, DRP-1, Collapsin response mediator protein 1, CRMP-1, Unc-33-like phosphoprotein 3, ULIP-3, CRMP1, DPYSL1, ULIP3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CRMP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CRMP1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRMP1 |
|---|---|
| Synonyms | DPYSL1, ULIP3 |
| Function | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cell projection, growth cone {ECO:0000250|UniProtKB:P97427}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P97427}. Perikaryon {ECO:0000250|UniProtKB:P97427}. Note=Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity) {ECO:0000250|UniProtKB:P97427, ECO:0000269|PubMed:11562390} |
| Tissue Location | Brain. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Stelzl,U., (2005) Cell 122 (6), 957-968 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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$ 389.00
Cat# AI11962
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