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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GPR161 antibody - N-terminal region   

GPR161 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • IHC - GPR161 antibody - N-terminal region AI12005
    Rabbit Anti-GPR161 Antibody
    Paraffin Embedded Tissue: Human Kidney
    Cellular Data: Epithelial cells of renal tubule
    Antibody Concentration: 4.0-8.0 μg/ml
    Magnification: 400X
  • WB - GPR161 antibody - N-terminal region AI12005

    WB Suggested Anti-GPR161 Antibody Titration: 2.5μg/ml
    Positive Control: HepG2 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N6U8
Other Accession NM_153832, NP_722561
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Dog
Predicted Human, Mouse, Rabbit, Pig, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 58kDa
Additional Information
Gene ID 23432
Alias Symbol FLJ33952, RE2
Other Names G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-GPR161 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGPR161 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR161
Function Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Cellular Location Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).
Research Areas
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Small,K.M., FEBS Lett. 516 (1-3), 253-256 (2002)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 232.00
Cat# AI12005
(40 western blots)
Availability: 2-3 days
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