|Other Accession||NM_001204880, NP_003329|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Goat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Mouse, Zebrafish, Pig, Chicken, Goat, Dog|
|Alias Symbol||E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A|
|Other Names||Ubiquitin-conjugating enzyme E2 D1, 22.214.171.124, Stimulator of Fe transport, SFT, UBC4/5 homolog, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2(17)KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1, UBE2D1, SFT, UBC5A, UBCH5, UBCH5A|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-UBE2D1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||UBE2D1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||SFT, UBC5A, UBCH5, UBCH5A|
|Function||Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.|
|Tissue Location||Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis|
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