|Other Accession||NM_016496, NP_057580|
|Reactivity||Human, Mouse, Rat, Rabbit, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Dog|
|Alias Symbol||HSPC240, MARCH-II, RNF172|
|Other Names||E3 ubiquitin-protein ligase MARCH2, 6.3.2.-, Membrane-associated RING finger protein 2, Membrane-associated RING-CH protein II, MARCH-II, RING finger protein 172, MARCH2, RNF172|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-MARCH2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MARCH2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein|
|Tissue Location||Broadly expressed.|
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