|Other Accession||NM_020870, NP_065921|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Mouse, Rat, Rabbit, Pig, Chicken, Horse, Guinea Pig, Dog|
|Alias Symbol||FLJ21602, KIAA1494, POSH, RNF142, SH3MD2|
|Other Names||E3 ubiquitin-protein ligase SH3RF1, 6.3.2.-, Plenty of SH3s, Protein POSH, RING finger protein 142, SH3 domain-containing RING finger protein 1, SH3 multiple domains protein 2, SH3RF1, KIAA1494, POSH, RNF142, SH3MD2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SH3RF1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SH3RF1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1494, POSH, RNF142, SH3MD2|
|Function||Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane. Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.|
|Cellular Location||Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cytoplasm. Golgi apparatus, trans- Golgi network. Note=Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network|
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