|Other Accession||NM_022079, NP_071362|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Bovine, Guinea Pig, Dog|
|Alias Symbol||DKFZP564G092, KIAA1593|
|Other Names||Probable E3 ubiquitin-protein ligase HERC4, 6.3.2.-, HECT domain and RCC1-like domain-containing protein 4, HERC4, KIAA1593|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HERC4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HERC4 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.|
|Cellular Location||Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution|
|Tissue Location||Expressed in brain and testis and detected in heart and placenta.|
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