|Other Accession||NM_032271, NP_115647|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||DKFZp586I021, MGC7807, RFWD1, RNF119|
|Other Names||E3 ubiquitin-protein ligase TRAF7, 6.3.2.-, RING finger and WD repeat-containing protein 1, RING finger protein 119, TNF receptor-associated factor 7, TRAF7, RFWD1, RNF119|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TRAF7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TRAF7 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.|
|Cellular Location||Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm|
|Tissue Location||Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta|
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