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TRAF7 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q6Q0C0 |
| Other Accession | NM_032271, NP_115647 |
| Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74kDa |
| Gene ID | 84231 |
|---|---|
| Alias Symbol | DKFZp586I021, MGC7807, RFWD1, RNF119 |
| Other Names | E3 ubiquitin-protein ligase TRAF7, 6.3.2.-, RING finger and WD repeat-containing protein 1, RING finger protein 119, TNF receptor-associated factor 7, TRAF7, RFWD1, RNF119 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TRAF7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TRAF7 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRAF7 |
|---|---|
| Synonyms | RFWD1, RNF119 |
| Function | E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3- mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). |
| Cellular Location | Cytoplasmic vesicle. Cytoplasm. Nucleus Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm |
| Tissue Location | Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Xu,L.G.,(2004)J.Biol.Chem.279(17),17278-17282ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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$ 389.00
Cat# AI12268
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