|Other Accession||NM_001098638, NP_001092108|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Rabbit, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Other Names||E3 ubiquitin-protein ligase RNF169, 6.3.2.-, RING finger protein 169, RNF169, KIAA1991|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RNF169 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RNF169 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair.|
|Cellular Location||Nucleus, nucleoplasm. Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products|
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