|Other Accession||NM_001010915, NP_001010915|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Mouse, Rat, Chicken, Guinea Pig, Dog|
|Alias Symbol||DKFZp686F01145, DKFZp686G24132, HACD4|
|Other Names||Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4, 220.127.116.11, 3-hydroxyacyl-CoA dehydratase 4, HACD4, Protein tyrosine phosphatase-like protein PTPLAD2, Protein-tyrosine phosphatase-like A domain-containing protein 2, PTPLAD2, HACD4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PTPLAD2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PTPLAD2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in leukocytes, and low expression in heart, spleen, kidney, and placenta|
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