|Other Accession||NM_001039479, NP_001034568|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rabbit, Pig, Chicken, Bovine, Dog|
|Other Names||Apoptosis-resistant E3 ubiquitin protein ligase 1, 6.3.2.-, AREL1, KIAA0317|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-KIAA0317 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KIAA0317 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.|
|Cellular Location||Cytoplasm, cytosol|
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