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C19orf28 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q6NUT3 |
| Other Accession | NM_001042680, NP_001036145 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51kDa |
| Gene ID | 126321 |
|---|---|
| Alias Symbol | MGC20700, PP3501, C19orf28 |
| Other Names | Major facilitator superfamily domain-containing protein 12, MFSD12, C19orf28 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-C19orf28 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | C19orf28 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MFSD12 {ECO:0000303|PubMed:29025994, ECO:0000312|HGNC:HGNC:28299} |
|---|---|
| Function | Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation (PubMed:33208952, PubMed:37751742). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis (PubMed:33208952, PubMed:37751742). |
| Cellular Location | Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed, with high expression in primary melanocytes. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI12528
Ordering Information
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