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FICD antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9BVA6 |
| Other Accession | NM_007076, NP_009007 |
| Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52kDa |
| Gene ID | 11153 |
|---|---|
| Alias Symbol | HYPE, MGC5623, UNQ3041, hip13, HIP13 |
| Other Names | Adenosine monophosphate-protein transferase FICD, 2.7.7.n1, AMPylator FICD, FIC domain-containing protein, Huntingtin yeast partner E, Huntingtin-interacting protein 13, HIP-13, Huntingtin-interacting protein E, FICD, HIP13, HYPE |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FICD antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | FICD antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FICD (HGNC:18416) |
|---|---|
| Function | Protein that can both mediate the addition of adenosine 5'- monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
| Tissue Location | Ubiquitous.. |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Clark,H.F.,(2003)GenomeRes.13(10),2265-2270ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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$ 389.00
Cat# AI12719
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