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Ghitm antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q91VC9 |
| Other Accession | NM_078478, NP_510963 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37kDa |
| Gene ID | 66092 |
|---|---|
| Alias Symbol | 1010001P14Rik, C77840, PTD010, MICS1 |
| Other Names | Growth hormone-inducible transmembrane protein, Mitochondrial morphology and cristae structure 1, MICS1, Ghitm, Mics1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ghitm antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ghitm antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ghitm |
|---|---|
| Synonyms | Mics1 |
| Function | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:35715207). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:35715207). Required for the mitochondrial tubular network and cristae organization (PubMed:35715207). Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (By similarity). |
| Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9H3K2}; Multi-pass membrane protein |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI12738
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