|Other Accession||NM_008044, NP_032070|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rabbit, Pig, Chicken, Horse, Guinea Pig, Dog|
|Alias Symbol||FA, FARR, Frda, X25|
|Other Names||Frataxin, mitochondrial, Fxn, 184.108.40.206, Frataxin intermediate form, Frataxin mature form, Fxn, Frda|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Fxn antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Fxn antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity).|
|Cellular Location||Cytoplasm. Mitochondrion Note=PubMed:17597094 describes localization exclusively in mitochondria|
|Tissue Location||Heart, liver, skeletal muscle, kidney, spleen and thymus. Weakly expressed in the brain and lung|
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