|Application ||WB, IHC|
|Other Accession||NM_015865, NP_056949|
|Reactivity||Human, Mouse, Pig, Goat, Sheep, Horse, Bovine, Dog|
|Predicted||Human, Pig, Goat, Dog|
|Alias Symbol||FLJ33745, FLJ41687, HUT11, HsT1341, JK, RACH1, UT-B1, UT1, UTE|
|Other Names||Urea transporter 1, Solute carrier family 14 member 1, Urea transporter, erythrocyte, SLC14A1, HUT11, JK, RACH1, UT1, UTE|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SLC14A1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SLC14A1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HUT11, JK, RACH1, UT1, UTE|
|Function||Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Basolateral cell membrane; Multi-pass membrane protein. Note=Restricted to the basolateral membrane in various portions of the urothelium.|
|Tissue Location||Detected in erythrocytes (at protein level). Erythrocytes.|
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