|Other Accession||NM_024887, NP_079163|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Horse, Bovine, Dog|
|Alias Symbol||CIT, CPT, DS, FLJ13102, HDS, RP59|
|Other Names||Dehydrodolichyl diphosphate syntase complex subunit DHDDS, 220.127.116.11, Cis-isoprenyltransferase, CIT, Cis-IPTase, Epididymis tissue protein Li 189m, DHDDS, HDS|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-DHDDS antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||DHDDS antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Note=colocalizes with calnexin|
|Tissue Location||Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
Endo S.,et al.Biochim. Biophys. Acta 1625:291-295(2003).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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