|Other Accession||NM_177439, NP_803188|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Alias Symbol||CDLIV, JM23, MRX44, MRX9, SPB1, TRM7|
|Other Names||Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2, 220.127.116.116, Cap methyltransferase 2, Cap2 2'O-ribose methyltransferase 2, HMTr2, MTr2, FtsJ methyltransferase domain-containing protein 1, Protein adrift homolog, CMTR2, AFT, FTSJD1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-FTSJ1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FTSJ1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.|
|Cellular Location||Nucleus. Cytoplasm. Membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zan Q.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Werner M.,et al.Nucleic Acids Res. 39:4756-4768(2011).
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