|Other Accession||NM_178557, NP_848652|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||CML3, FLJ37478, MGC117272, NAT8-LIKE, NACED|
|Other Names||N-acetylaspartate synthetase, NAA synthetase, 220.127.116.11, Camello-like protein 3, N-acetyltransferase 8-like protein, NAT8L, CML3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-NAT8L antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NAT8L antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.|
|Cellular Location||Cytoplasm. Membrane; Single- pass membrane protein. Microsome membrane; Single-pass membrane protein Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane; Single-pass membrane protein. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment|
|Tissue Location||Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Hillier L.W.,et al.Nature 434:724-731(2005).
Brandenberger R.,et al.Nat. Biotechnol. 22:707-716(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Popsueva A.E.,et al.Dev. Biol. 234:483-496(2001).
Arun P.,et al.Neurochem. Int. 55:219-225(2009).
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